Linked Life Data

19848154

Source:http://linkedlifedata.com/resource/pubmed/id/19848154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2009-10-23
pubmed:abstractText
Antibacterial and bactericidal effects of a C60 derivative prepared via excess ozonation of C60 aggregates in water were investigated using Escherichia coli as a representative microorganism. Ozonated C60 up to 10 mg/L did not cause significant growth inhibition nor inactivation of E. coli in the absence of either oxygen or light. However, it readily inactivated E. coli in the presence of both oxygen and light at much faster rate than parent C60 aggregates, suggesting involvement of photochemical generation of reactive oxygen species (ROS). Among ROS, hydroxyl radical was found as a primary agent for the cell inactivation. Little surface protein release and concurrent intercellular enzyme degradation during the course of E. coli inactivation, along with visual evidence obtained from transmission electron microscopic analysis, collectively indicated that the mechanism of E. coli inactivation by ozonated C60 involves efficient penetration of ozonated C60 into E. coli and subsequent photochemical production of hydroxyl radical within the cell cytoplasm. These findings suggest that oxidative transformation of C60 can lead to increased toxicity in addition to increased water solubility and reduced size, warranting further studies on other potential chemical derivatization possible in natural and engineered environments for an accurate assessment of environmental impact of this class of materials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0013-936X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7410-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Escherichia coli inactivation by water-soluble, ozonated C60 derivative: kinetics and mechanisms.
pubmed:affiliation
School of Civil and Environmental Engineering, Georgia Institute of Technology, 200 Bobby Dodd Way, Atlanta, Georgia 30332, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.