Linked Life Data

19847669

Source:http://linkedlifedata.com/resource/pubmed/id/19847669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-9-17
pubmed:abstractText
Glomerulosclerosis is considered to be the final pathway leading to the progressive loss of renal function in several kidney diseases, transforming growth factor ?1 (TGF-?1) plays a critical role in glomerulosclerosis. However, the mechanisms of TGF-?1 stimulating glomerulosclerosis remain poorly understood. Here we report that TGF-?1-induced expression of fibronectin (FN) depends on the activity of aldose reductase (AR) in human mesangial cells (HMCs).The results show that TGF-?1 increased the expression of FN, which attenuated by pharmacological inhibition of AR or knockdown of the enzyme by small interfering RNA (siRNA). MAPKs (ERK, JNK and p38) signalling pathways were activated in HMCs after stimulated by TGF-?1, inhibition of AR blunted the activation ERK, p38 and JNK signalling pathways. These changes were associated with decreased TGF-?1-induced expression of FN. These results indicate that AR is a potent regulator of TGF-?1 induced expression of FN in human mesangial cells: it suggests that inhibition of this enzyme may be useful to prevented extracellular matrix (ECM) deposition in glomerulosclerosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1573-4978
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3097-103
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Aldose reductase is a potent regulator of TGF-?1 induced expression of fibronectin in human mesangial cells.
pubmed:affiliation
Department of Pathology, Shanghai Medical College, Fudan University, Box 230, 138 Yixueyuan Road, 200032, Shanghai, China. ann-200018@163.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't