Linked Life Data

19846950

Source:http://linkedlifedata.com/resource/pubmed/id/19846950

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-10-22
pubmed:abstractText
Pseudomyxoma peritonei (PMP) is a clinical condition characterized by diffuse intraabdominal spread of mucinous tumor implants that form on peritoneal surfaces. To complement the efficacy of cytoreductive surgery, an effective cytotoxic drug is required as an intraperitoneal agent for microscopic cytoreduction locoregionally. To develop a model for drug discovery, human pseudomyxoma peritonei tumor implants consisting of a mixture of mucin and epithelial cells were injected into the peritoneal cavity of CBH/rnu/rnu rats. A fixed quantity of tumor (2 ml) was implanted in each of the 9 male rats. Over 90 days, all rats developed PMP indicating that this in vivo animal model may become useful platform in a drug discovery program to allow drug efficacy testing against human PMP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1791-7530
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4051-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
In vivo model of pseudomyxoma peritonei for novel candidate drug discovery.
pubmed:affiliation
Department of Surgery, University of New South Wales, St. George Hospital, Kogarah, Sydney, NSW 2217, Australia.
pubmed:publicationType
Journal Article