Source:http://linkedlifedata.com/resource/pubmed/id/19846298
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
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| pubmed:dateCreated |
2009-11-5
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| pubmed:abstractText |
A variety of basic, heterocyclic templates has been reported as potassium-competitive, acid pump antagonists. Herein, we report a comparison of potencies of these templates and others to establish which offers the best start point for further systematic optimisation. Modifications were carried out to improve the developability profile of the more potent 1H-pyrrolo[2,3-c]pyridine template, affording molecules with improved overall in vitro characteristics versus the reported clinical candidate AR-H047108, and comparable to the clinically efficacious AZD-0865.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6813-7
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| pubmed:meshHeading |
pubmed-meshheading:19846298-Binding, Competitive,
pubmed-meshheading:19846298-Drug Design,
pubmed-meshheading:19846298-H(+)-K(+)-Exchanging ATPase,
pubmed-meshheading:19846298-Heterocyclic Compounds,
pubmed-meshheading:19846298-Molecular Structure,
pubmed-meshheading:19846298-Pyridines,
pubmed-meshheading:19846298-Stereoisomerism,
pubmed-meshheading:19846298-Structure-Activity Relationship
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).
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| pubmed:affiliation |
Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex CM19 5AW, United Kingdom. Terry.A.Panchal@gsk.com
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| pubmed:publicationType |
Journal Article
|