Source:http://linkedlifedata.com/resource/pubmed/id/19846295
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
23
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pubmed:dateCreated |
2009-11-5
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pubmed:abstractText |
Bioassay-guided fractionation of the chloroform-soluble fraction of Morus bombycis, using an in vitro PTP1B inhibitory assay led to the identification of three 2-arylbenzofurans, albafuran A (1), mulberrofuran W (2) and mulberrofuran D (6), along with three chalcone-derived Diels-Alder products, kuwanon J (3), kuwanon R (4), and kuwanon V (5). Compounds 1-6 showed remarkable inhibitory activity against PTP1B with IC(50) values ranging from 2.7 to 13.8 microM. Inhibition kinetics were analyzed by Lineweaver-Burk plots, which suggested that compounds 1-6 inhibited PTP1B in a mixed-type manner. The present results indicate that the respective lipophilic and hydroxyl groups of 2-arylbenzofurans and chalcone-derived Diels-Alder products play an important role in inhibition of PTP1B.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6759-61
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pubmed:meshHeading |
pubmed-meshheading:19846295-Benzofurans,
pubmed-meshheading:19846295-Drug Design,
pubmed-meshheading:19846295-Enzyme Inhibitors,
pubmed-meshheading:19846295-Molecular Structure,
pubmed-meshheading:19846295-Morus,
pubmed-meshheading:19846295-Plant Extracts,
pubmed-meshheading:19846295-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:19846295-Stereoisomerism,
pubmed-meshheading:19846295-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.
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pubmed:affiliation |
Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon 305-333, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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