Linked Life Data

19845626

Source:http://linkedlifedata.com/resource/pubmed/id/19845626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-10-22
pubmed:abstractText
Since the birth of molecular biology it has been generally assumed that most genetic information is transacted by proteins, and that RNA plays an intermediary role. This led to the subsidiary assumption that the vast tracts of noncoding sequences in the genomes of higher organisms are largely nonfunctional, despite the fact that they are transcribed. These assumptions have since become articles of faith, but they are not necessarily correct. I propose an alternative evolutionary history whereby developmental and cognitive complexity has arisen by constructing sophisticated RNA-based regulatory networks that interact with generic effector complexes to control gene expression patterns and the epigenetic trajectories of differentiation and development. Environmental information can also be conveyed into this regulatory system via RNA editing, especially in the brain. Moreover, the observations that RNA-directed epigenetic changes can be inherited raises the intriguing question: has evolution learnt how to learn?
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-46
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Deconstructing the dogma: a new view of the evolution and genetic programming of complex organisms.
pubmed:affiliation
Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072, Australia. j.mattick@imb.uq.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't