Linked Life Data

19845593

Source:http://linkedlifedata.com/resource/pubmed/id/19845593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-12-21
pubmed:abstractText
Blockade of the B7: CD28 costimulatory pathway has emerged as a promising therapy to prevent allograft rejection. However, this pathway has also been demonstrated to be important for the generation and maintenance of regulatory T cells. In this study, we investigated the role of the B7: CD28 pathway in the 'bm12 into B6' MHC class II-mismatched vascularized cardiac transplant model of chronic rejection. Allograft rejection was remarkably accelerated in B6 background B7DKO and CD28KO recipients compared with B6 wild-type (WT) recipients. Allograft rejection was associated with a significantly enhanced Th1/Th2 alloreactivity and marked reduction in the ratio of regulatory T cells to CD4(+) effector/memory cells. We noted that administration of anti-B7-1 and anti-B7-2 mAb prior to transplantation also accelerated allograft rejection. Furthermore, depleting CD25(+) cells in B6 WT recipients of bm12 hearts prior to transplant also precipitated rejection at a similar rate. Neither B7/CD28 deficiency nor CD25 depletion affected graft survival in single MHC class I-mismatched (bm1 into B6) recipients. This study highlights the paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched model, in which the B7: CD28 pathway is demonstrated to be important in preventing rejection through the generation and maintenance of Tregs.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-10795741, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-10934151, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-10975872, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-11418642, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-12865411, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-14500627, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-14617200, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-15749914, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-15771580, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-16120857, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-18172549, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-18212277, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-18848987, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-19047438, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-2277293, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-4583148, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-8808683, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-9632449, http://linkedlifedata.com/resource/pubmed/commentcorrection/19845593-9653096
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1600-6143
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2837-44
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model.
pubmed:affiliation
Transplantation Research Center, Renal Division, Brigham & Women's Hospital, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural