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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-11
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pubmed:abstractText |
The PNPLA3 I148M variant (rs738409) is robustly associated with hepatic steatosis. Intriguingly, initial findings in cohorts with a mean body mass index (BMI) of 30 kg m(-2) also suggested that it is associated with elevated liver enzymes but not with insulin resistance and dyslipidaemia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1476-5497
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pubmed:author |
pubmed-author:BaroneM CMC,
pubmed-author:CapocciaDD,
pubmed-author:DashSS,
pubmed-author:IacovinoMM,
pubmed-author:IncaniMM,
pubmed-author:LeonettiFF,
pubmed-author:MaglioCC,
pubmed-author:O'RahillySS,
pubmed-author:RomeoSS,
pubmed-author:SavageD BDB,
pubmed-author:SentinelliFF,
pubmed-author:YeoG S HGS
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-4
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pubmed:meshHeading |
pubmed-meshheading:19844213-Adult,
pubmed-meshheading:19844213-Alanine Transaminase,
pubmed-meshheading:19844213-Aspartate Aminotransferases,
pubmed-meshheading:19844213-Biological Markers,
pubmed-meshheading:19844213-Body Mass Index,
pubmed-meshheading:19844213-Fatty Liver,
pubmed-meshheading:19844213-Female,
pubmed-meshheading:19844213-Genetic Predisposition to Disease,
pubmed-meshheading:19844213-Genetic Variation,
pubmed-meshheading:19844213-Genotype,
pubmed-meshheading:19844213-Glucose Tolerance Test,
pubmed-meshheading:19844213-Humans,
pubmed-meshheading:19844213-Insulin Resistance,
pubmed-meshheading:19844213-Italy,
pubmed-meshheading:19844213-Lipase,
pubmed-meshheading:19844213-Male,
pubmed-meshheading:19844213-Membrane Proteins,
pubmed-meshheading:19844213-Obesity, Morbid
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pubmed:year |
2010
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pubmed:articleTitle |
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.
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pubmed:affiliation |
Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK. sr517@medschl.cam.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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