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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2009-11-5
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pubmed:abstractText |
Lung cancers with epidermal growth factor receptor (EGFR)-activating mutations show good clinical response to gefitinib and erlotinib, selective tyrosine kinase inhibitors (TKI) to EGFR, but these tumors invariably develop drug resistance. Host stromal cells have been found to have a considerable effect on the behavior of cancer cells. Little is known, however, about the role of host cells on the sensitivity of cancer cells to receptor TKIs. We have therefore assessed the effect of crosstalk between stromal cells and lung cancer cells harboring EGFR mutations on susceptibility to EGFR-TKIs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:CHUE PEP,
pubmed-author:KayanoYoshiyukiY,
pubmed-author:MatsumotoIsaoI,
pubmed-author:MatsumotoKunioK,
pubmed-author:NishiokaYasuhikoY,
pubmed-author:OdaMakotoM,
pubmed-author:SoneSaburoS,
pubmed-author:VighB JBJ,
pubmed-author:WatanabeGoG,
pubmed-author:YamadaTadaakiT,
pubmed-author:YanoSeijiS
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6630-8
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pubmed:meshHeading |
pubmed-meshheading:19843665-Animals,
pubmed-meshheading:19843665-Antineoplastic Agents,
pubmed-meshheading:19843665-Cell Line, Tumor,
pubmed-meshheading:19843665-Coculture Techniques,
pubmed-meshheading:19843665-Drug Resistance, Neoplasm,
pubmed-meshheading:19843665-Fibroblasts,
pubmed-meshheading:19843665-Hepatocyte Growth Factor,
pubmed-meshheading:19843665-Humans,
pubmed-meshheading:19843665-Lung Neoplasms,
pubmed-meshheading:19843665-Mice,
pubmed-meshheading:19843665-Mice, Nude,
pubmed-meshheading:19843665-Mice, SCID,
pubmed-meshheading:19843665-Mutation,
pubmed-meshheading:19843665-Protein Kinase Inhibitors,
pubmed-meshheading:19843665-Quinazolines,
pubmed-meshheading:19843665-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19843665-Receptor Cross-Talk,
pubmed-meshheading:19843665-Stromal Cells,
pubmed-meshheading:19843665-Xenograft Model Antitumor Assays
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pubmed:year |
2009
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pubmed:articleTitle |
Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.
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pubmed:affiliation |
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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