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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-9
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pubmed:abstractText |
This study investigated the anti-obesity effects of fucoxanthin in diet-induced obesity mice fed a high-fat diet (20% fat, wt/wt). The mice were supplemented with two doses of fucoxanthin (0.05 and 0.2%, wt/wt) for 6 wk. Fucoxanthin significantly lowered body weight and visceral fat-pads weights compared with the control group without altering food intake. In epididymal adipose tissue of fucoxanthin-fed mice, adipocyte sizes and mRNA expression of lipogenic and fatty acid beta-oxidation enzymes were significantly altered in a dose-dependent manner. Plasma leptin level was significantly lower in the fucoxanthin groups than in the control group, while the adiponectin level was elevated. Fucoxanthin significantly down-regulated various lipogenic enzyme activities in epididymal adipose tissue with a simultaneous decrease in fatty acid beta-oxidation activity. The 0.2% fucoxanthin supplement led to increase mRNA expression of uncoupling protein-1 (UCP-1) and UCP-3 in brown adipose tissue and that of UCP-2 in the epididymal white adipose tissue. However, the 0.05% fucoxanthin only elevated UCP-1 mRNA expression in epididymal white adipose tissue. These results suggest that the anti-obesity effect of fucoxanthin could be mediated by altering lipid-regulating enzymes and UCPs in the visceral fat tissues and plasma adipokine levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adipokines,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Obesity Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Uncoupling Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthophylls,
http://linkedlifedata.com/resource/pubmed/chemical/fucoxanthin,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein 3
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1613-4133
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1603-11
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pubmed:meshHeading |
pubmed-meshheading:19842104-Adipokines,
pubmed-meshheading:19842104-Adipose Tissue, Brown,
pubmed-meshheading:19842104-Animals,
pubmed-meshheading:19842104-Anti-Obesity Agents,
pubmed-meshheading:19842104-Cell Size,
pubmed-meshheading:19842104-Dietary Fats,
pubmed-meshheading:19842104-Intra-Abdominal Fat,
pubmed-meshheading:19842104-Ion Channels,
pubmed-meshheading:19842104-Lipid Metabolism,
pubmed-meshheading:19842104-Male,
pubmed-meshheading:19842104-Mice,
pubmed-meshheading:19842104-Mice, Inbred C57BL,
pubmed-meshheading:19842104-Mitochondrial Proteins,
pubmed-meshheading:19842104-Obesity,
pubmed-meshheading:19842104-Random Allocation,
pubmed-meshheading:19842104-Time Factors,
pubmed-meshheading:19842104-Uncoupling Agents,
pubmed-meshheading:19842104-Undaria,
pubmed-meshheading:19842104-Weight Gain,
pubmed-meshheading:19842104-Xanthophylls
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pubmed:year |
2009
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pubmed:articleTitle |
Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice.
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pubmed:affiliation |
Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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