Linked Life Data

19841571

Source:http://linkedlifedata.com/resource/pubmed/id/19841571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2009-11-12
pubmed:abstractText
Recent studies on HIV integration in the human genome have reported on certain preferences for chromosomes, genes, or repetitive elements. We performed a high-resolution meta-analysis of public available HIV vector insertion sites (n = 46 114) and detected that HIV vectors significantly spared a region of 1 kb upstream and downstream to transcription start sites (TSS). Genes with the TSS being located within this 'insertional gap' had significantly lower expression levels than those with the TSS located outside the gap. Our data show an either unfavored and/or sterically inaccessible region located + or - 1 kb around TSS of transcriptionally active genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1473-5571
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2535-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cold spots in hot spots: transcription start sites of active genes are spared from HIV vector integration.
pubmed:affiliation
Clinical Cooperation Unit Molecular Oncology of Solid Tumors, German Cancer Research Center (DKFZ), Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Meta-Analysis