Linked Life Data

19838709

Source:http://linkedlifedata.com/resource/pubmed/id/19838709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-2-19
pubmed:abstractText
Iron overload and oxidative stress are main pathophysiological features of HbE/beta thalassemia patients. Glutathione S-transferase genes (GSTT1 and GSTM1) are well known detoxification agents, and any mutation in the gene is known to cause oxidative damage. This study was aimed to compare the prevalence of GST deletions in 240 HbE/beta thalassemia patients with 100 controls and to determine role of deletions on iron overload. We observed significantly higher frequency of GSTT1 (P = 0.001) and GSTT1/GSTM1 (P = 0.03) in comparison to controls. Patients who had null genotype for both the alleles, i.e., GSTT1/GSTM1 had significantly higher levels of serum iron (P = 0.007) and serum ferritin (P = 0.001) than patients with normal genotype for GST deletions. This is the first study to prove the role of GST gene deletions with iron overload in HbE/beta thalassemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1432-0584
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
411-4
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients.
pubmed:affiliation
Department of Hematology, I.R.C.H. Building (first floor), All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi 110 029, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't