| pubmed-article:19838194 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19838194 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:19838194 | lifeskim:mentions | umls-concept:C1422539 | lld:lifeskim |
| pubmed-article:19838194 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:19838194 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19838194 | pubmed:dateCreated | 2009-10-28 | lld:pubmed |
| pubmed-article:19838194 | pubmed:abstractText | Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2. We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome. CRLF2 alteration was associated with activating JAK mutations, and expression of human P2RY8-CRLF2 together with mutated mouse Jak2 resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL. | lld:pubmed |
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| pubmed-article:19838194 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19838194 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19838194 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19838194 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19838194 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19838194 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19838194 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19838194 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19838194 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19838194 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19838194 | pubmed:issn | 1546-1718 | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:TomP APA | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:WillmanCheryl... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:PuiChing-HonC... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:ZhangJinghuiJ | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:MaJingJ | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:HeeremaNyla... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:RaimondiSusan... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:CarrollAndrew... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:Coustan-Smith... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:BassoGiuseppe... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:WilliamsRicha... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:DowningJames... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:MullighanChar... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:MikhailFady... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:PessionAndrea... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:LeeMaryM | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:CarrollWillia... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:HungerStephen... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:RabinKaren... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:HarveyRichard... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:Collins-Under... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:PhillipsLetha... | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:ChengJinjunJ | lld:pubmed |
| pubmed-article:19838194 | pubmed:author | pubmed-author:LoudinMichael... | lld:pubmed |
| pubmed-article:19838194 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19838194 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:19838194 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19838194 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19838194 | pubmed:pagination | 1243-6 | lld:pubmed |
| pubmed-article:19838194 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:meshHeading | pubmed-meshheading:19838194... | lld:pubmed |
| pubmed-article:19838194 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19838194 | pubmed:articleTitle | Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. | lld:pubmed |
| pubmed-article:19838194 | pubmed:publicationType | Journal Article | lld:pubmed |
