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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-28
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pubmed:abstractText |
Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2. We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome. CRLF2 alteration was associated with activating JAK mutations, and expression of human P2RY8-CRLF2 together with mutated mouse Jak2 resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-10570284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-10675114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-11863413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-14993294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-15361874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-16142237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-16785889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-16798110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-17054672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-17234643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-17344859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-17487742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-17554380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-17971484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-18358930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-18408710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-18450510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-18779404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-18805579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-18927438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-19039135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-19052058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-19120350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-19129520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-19139078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-19299724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-19470474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-5910392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19838194-831755
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:BassoGiuseppeG,
pubmed-author:CarrollAndrew JAJ,
pubmed-author:CarrollWilliam LWL,
pubmed-author:ChengJinjunJ,
pubmed-author:Collins-UnderwoodJ RacquelJR,
pubmed-author:Coustan-SmithElaineE,
pubmed-author:DowningJames RJR,
pubmed-author:HarveyRichard CRC,
pubmed-author:HeeremaNyla ANA,
pubmed-author:HungerStephen PSP,
pubmed-author:LeeMaryM,
pubmed-author:LoudinMichael GMG,
pubmed-author:MaJingJ,
pubmed-author:MikhailFady MFM,
pubmed-author:MullighanCharles GCG,
pubmed-author:PessionAndreaA,
pubmed-author:PhillipsLetha A ALA,
pubmed-author:PuiChing-HonCH,
pubmed-author:RabinKaren RKR,
pubmed-author:RaimondiSusana CSC,
pubmed-author:TomP APA,
pubmed-author:WilliamsRichard TRT,
pubmed-author:WillmanCheryl LCL,
pubmed-author:ZhangJinghuiJ
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1243-6
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19838194-Amino Acid Sequence,
pubmed-meshheading:19838194-Animals,
pubmed-meshheading:19838194-Base Sequence,
pubmed-meshheading:19838194-Cell Line,
pubmed-meshheading:19838194-Chromosome Deletion,
pubmed-meshheading:19838194-Down Syndrome,
pubmed-meshheading:19838194-Gene Rearrangement,
pubmed-meshheading:19838194-Humans,
pubmed-meshheading:19838194-Janus Kinase 2,
pubmed-meshheading:19838194-Mice,
pubmed-meshheading:19838194-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19838194-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19838194-Receptors, Cytokine,
pubmed-meshheading:19838194-Receptors, Purinergic P2,
pubmed-meshheading:19838194-Recombinant Fusion Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
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pubmed:publicationType |
Journal Article
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