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rdf:type |
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lifeskim:mentions |
umls-concept:C0020792,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0243076,
umls-concept:C0289174,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C0682002,
umls-concept:C1319313,
umls-concept:C1554184,
umls-concept:C1883254
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pubmed:issue |
22
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pubmed:dateCreated |
2009-11-2
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pubmed:abstractText |
The discovery of a series of 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles, dual acting norepinephrine reuptake inhibitors (NRIs) and 5-HT(2A) receptor antagonists, is described. The synthesis and structure-activity relationship (SAR) of this novel series of compounds is also presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:AlfinitoPeterP,
pubmed-author:BrayJenifer AJA,
pubmed-author:CoghlanRichard DRD,
pubmed-author:CosmiScott ASA,
pubmed-author:DeecherDarlene CDC,
pubmed-author:HeffernanGavin DGD,
pubmed-author:HuseltonChristineC,
pubmed-author:JohnstonGrace HGH,
pubmed-author:KenneyThomasT,
pubmed-author:KouryElizabethE,
pubmed-author:LiYanfangY,
pubmed-author:MahaneyPaige EPE,
pubmed-author:ManasEric SES,
pubmed-author:McDevittRobert ERE,
pubmed-author:RobichaudAlbert JAJ,
pubmed-author:TrybulskiEugene JEJ,
pubmed-author:WinnekerRichard CRC
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7802-15
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19836247-Biological Transport,
pubmed-meshheading:19836247-Cell Line,
pubmed-meshheading:19836247-Humans,
pubmed-meshheading:19836247-Indoles,
pubmed-meshheading:19836247-Neurotransmitter Uptake Inhibitors,
pubmed-meshheading:19836247-Norepinephrine,
pubmed-meshheading:19836247-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:19836247-Serotonin 5-HT2 Receptor Antagonists,
pubmed-meshheading:19836247-Serotonin Antagonists,
pubmed-meshheading:19836247-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
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pubmed:affiliation |
Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. hefferg@wyeth.com
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pubmed:publicationType |
Journal Article
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