19833513

Source:http://linkedlifedata.com/resource/pubmed/id/19833513

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0042776, umls-concept:C0205250, umls-concept:C0243071, umls-concept:C1569792, umls-concept:C1579410
pubmed:issue	22
pubmed:dateCreated	2009-10-26
pubmed:abstractText	We report the preparation of 2'-alpha-F, 2'-beta-F and 2',2'-difluoro analogues of the leading anti-varicella zoster virus (VZV) pentylphenyl BCNA Cf 1743. VZV thymidine kinase showed the highest phosphorylating capacity for the beta-fluoro derivative, that retained equal antiviral potency as the parent compound. In contrast, the alpha-fluoro- and 2',2'-difluoro BCNA derivatives were markedly less (approximately 100-fold) antivirally active.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents, http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine, http://linkedlifedata.com/resource/pubmed/chemical/Cf 1743, http://linkedlifedata.com/resource/pubmed/chemical/Fluorides, http://linkedlifedata.com/resource/pubmed/chemical/Nucleosides, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidine Nucleosides, http://linkedlifedata.com/resource/pubmed/chemical/Thymidine Kinase
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	1464-3405
pubmed:author	pubmed-author:AndreiGracielaG, pubmed-author:BalzariniJanJ, pubmed-author:DerudasMarcoM, pubmed-author:HensonGeoffreyG, pubmed-author:McGuiganChristopherC, pubmed-author:QuintilianiMaurizioM, pubmed-author:SnoeckRobertR
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	19
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	6264-7
pubmed:meshHeading	pubmed-meshheading:19833513-Antiviral Agents, pubmed-meshheading:19833513-Bicyclo Compounds, pubmed-meshheading:19833513-Bromodeoxyuridine, pubmed-meshheading:19833513-Cell Line, pubmed-meshheading:19833513-Drug Design, pubmed-meshheading:19833513-Drug Interactions, pubmed-meshheading:19833513-Fluorides, pubmed-meshheading:19833513-HeLa Cells, pubmed-meshheading:19833513-Herpesvirus 3, Human, pubmed-meshheading:19833513-Humans, pubmed-meshheading:19833513-Microbial Sensitivity Tests, pubmed-meshheading:19833513-Models, Molecular, pubmed-meshheading:19833513-Nucleosides, pubmed-meshheading:19833513-Pyrimidine Nucleosides, pubmed-meshheading:19833513-Structure-Activity Relationship, pubmed-meshheading:19833513-Substrate Specificity, pubmed-meshheading:19833513-Thymidine Kinase, pubmed-meshheading:19833513-Virus Replication
pubmed:year	2009
pubmed:articleTitle	2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.
pubmed:affiliation	Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103XF, UK. mcguigan@cf.ac.uk
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't