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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2009-10-26
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pubmed:abstractText |
Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated alpha-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6298-302
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pubmed:meshHeading |
pubmed-meshheading:19833512-Actins,
pubmed-meshheading:19833512-Amino Acid Motifs,
pubmed-meshheading:19833512-Aorta, Thoracic,
pubmed-meshheading:19833512-Calcium-Binding Proteins,
pubmed-meshheading:19833512-Cell Differentiation,
pubmed-meshheading:19833512-Cell Proliferation,
pubmed-meshheading:19833512-Conserved Sequence,
pubmed-meshheading:19833512-Endothelium, Vascular,
pubmed-meshheading:19833512-Inhibitor of Differentiation Proteins,
pubmed-meshheading:19833512-Muscle, Smooth, Vascular,
pubmed-meshheading:19833512-Myocytes, Smooth Muscle,
pubmed-meshheading:19833512-Nuclear Proteins,
pubmed-meshheading:19833512-Peptides,
pubmed-meshheading:19833512-Phenotype,
pubmed-meshheading:19833512-Protein Binding,
pubmed-meshheading:19833512-Repressor Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype.
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pubmed:affiliation |
DISMAB-Dipartimento di Scienze Molecolari Applicate ai Biosistemi-Sez. Chimica Organica, Università degli Studi di Milano, I-20133 Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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