Linked Life Data

1983272

Source:http://linkedlifedata.com/resource/pubmed/id/1983272

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-9-26
pubmed:abstractText
Until recently, the endoplasmic reticulum (ER) of eukaryotic cells was regarded as an open corridor for the unregulated movement of newly-synthesized exocytotic proteins from their site of membrane translocation to the vesicles that ferry them from the transitional elements of the ER to the Golgi apparatus. Moreover, it was widely assumed that the folding and assembly of newly translocated polypeptides into their tertiary and quaternary structure is a spontaneous process that does not involve the intervention of other cellular proteins. In this article we review evidence that the ER is a highly discriminatory organelle that grants passage only to proteins that have attained an essentially native conformation, and summarize current knowledge about resident ER proteins that appear to facilitate and/or monitor protein folding and assembly in this organelle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1043-4682
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-72
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Transport and assembly processes in the endoplasmic reticulum.
pubmed:affiliation
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235.
pubmed:publicationType
Journal Article, Review