Linked Life Data

19832686

Source:http://linkedlifedata.com/resource/pubmed/id/19832686

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-10-16
pubmed:abstractText
The nature of the structural regression of the corpus luteum of pregnancy (PCL) was investigated in rats from day 19 of pregnancy (PRG19) through day 6 postpartum (PP6). A pre-partum decrease in tissue weight of the PCL during the last 4 days of pregnancy was apparent (nearly a 40% decrease) and seemed to parallel the fall in plasma progesterone. The PCL in normally lactating rats further experienced a gradual decrease in the postpartum period, but the reduction was significantly slowed by PP6 in non-lactating rats that were forced to wean from the parturient day (PPO). TUNEL analysis revealed that apoptotic cell death in the regressing PCL showed a 3-4 fold increase in signals after parturition (on PP3) but was fairly limited. Instead, luteal steroidogenic cells came to have cytoplasmic vacuoles by PRG21, and vacuoles increased through PP3. A decelerated decrease in PCL weight following forced weaning was potentially reversed by repeated administration of exogenous prolactin (10 IU) twice daily. This study adds evidence that structural regression of the rat PCL 1) starts to occur before the completion of functional regression, 2) involves a modest incidence of TUNEL-reactive apoptosis, and 3) is promoted by the suckling stimulus, presumably through the effects of prolactin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0289-0003
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
729-34
pubmed:dateRevised
2010-3-17
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Structural regression of the rat corpus luteum of pregnancy: relationship with functional regression, apoptotic cell death, and the suckling stimulus.
pubmed:affiliation
Laboratories of Veterinary Physiology, Kitasato University School of Veterinary Medicine, Towada, Aomori, Japan. kurusu@vmas.kitasato-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't