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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-1
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pubmed:abstractText |
The characteristics of carbapenem heteroresistance were studied in 14 apparently carbapenem-susceptible Acinetobacter baumannii isolates. The MICs for carbapenems were determined, and the isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and sequence typing (ST). Population analysis, testing of the stability of the heteroresistant subpopulations, and time-killing assays were performed. The agar dilution MICs of both imipenem and meropenem for the native isolates ranged from 0.25 to 4 mg/liter. The isolates belonged to nine PFGE types and exhibited seven ST allelic profiles. Population analysis revealed subpopulations that grew in the presence of imipenem at concentrations of up to 8 mg/liter and meropenem at concentrations of up to 32 mg/liter. The meropenem-heteroresistant subpopulations of 11 isolates exhibited stable resistance with MICs that ranged from 16 to >32 mg/liter; their PFGE profiles were identical to those of the native isolates. Time-kill assays with meropenem revealed less pronounced killing for 10 isolates. These findings indicate that meropenem pressure can produce meropenem-heteroresistant subpopulations that might subsequently select for highly resistant strains.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19828742-12842488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19828742-12856214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19828742-14585857,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19828742-20564828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19828742-3867331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19828742-7494007,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19828742-9817528
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1098-660X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4055-9
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:19828742-Acinetobacter Infections,
pubmed-meshheading:19828742-Acinetobacter baumannii,
pubmed-meshheading:19828742-Anti-Bacterial Agents,
pubmed-meshheading:19828742-Carbapenems,
pubmed-meshheading:19828742-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:19828742-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:19828742-Greece,
pubmed-meshheading:19828742-Humans,
pubmed-meshheading:19828742-Microbial Sensitivity Tests,
pubmed-meshheading:19828742-Polymerase Chain Reaction,
pubmed-meshheading:19828742-Thienamycins
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pubmed:year |
2009
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pubmed:articleTitle |
Heteroresistance to meropenem in carbapenem-susceptible Acinetobacter baumannii.
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pubmed:affiliation |
University of Thessaly, Mezourlo, Larissa, Greece. ado@med.uth.gr
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pubmed:publicationType |
Journal Article
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