Linked Life Data

19828121

Source:http://linkedlifedata.com/resource/pubmed/id/19828121

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-1-29
pubmed:abstractText
Thermo- and pH-sensitive chitosan-based nanoparticles were successfully prepared by one-pot polymerization of acrylic acid/chitosan with poly(N-isopropylacrylamide) (PNIPAM) macro-RAFT agent. The spherical and monodisperse nanoparticles were obtained with the diameters of about 100 nm at 25 degrees C (pH=6.5), and PNIPAM was anchored as the shell via the RAFT process. The disorder shell and the large aggregates were observed at 40 degrees C (pH=6.5); and the spherical nanoparticles broke up at 25 degrees C when pH was lowered to 3. This work may provide a facile "one-pot" method to prepare functionalized chitosan-based nanoparticles without N-phthaloylation of chitosan in the process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1879-0003
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
One-pot synthesis of pH- and thermo-sensitive chitosan-based nanoparticles by the polymerization of acrylic acid/chitosan with macro-RAFT agent.
pubmed:affiliation
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't