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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1991-6-5
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pubmed:databankReference | |
pubmed:abstractText |
The expression site for the variant surface glycoprotein (VSG) gene of Trypanosoma brucei contains several genes of unknown function (ESAGs, for expression site-associated genes). Among these, ESAG 4 shows homology to eukaryotic adenylate/guanylate cyclase genes, in the region encoding the presumptive enzyme catalytic domain. This gene belongs to a family of related sequences, and hybridizes to the genomic DNA of other trypanosomatids, such as Trypanosoma congolense, Trypanosoma vivax and Trypanosoma mega. While ESAG 4 is transcribed only in bloodstream forms by a RNA polymerase resistant to alpha-amanitin, at least three other members of this family are transcribed in both bloodstream and procyclic forms, by a RNA polymerase sensitive to the drug. These genes encode different putative transmembrane proteins showing high sequence conservation in the region corresponding to the adenylate/guanylate cyclase catalytic domain.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0166-6851
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
279-88
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1982555-Adenylate Cyclase,
pubmed-meshheading:1982555-Amino Acid Sequence,
pubmed-meshheading:1982555-Animals,
pubmed-meshheading:1982555-Base Sequence,
pubmed-meshheading:1982555-Cloning, Molecular,
pubmed-meshheading:1982555-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:1982555-Guanylate Cyclase,
pubmed-meshheading:1982555-Molecular Sequence Data,
pubmed-meshheading:1982555-Multigene Family,
pubmed-meshheading:1982555-Restriction Mapping,
pubmed-meshheading:1982555-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1982555-Transcription, Genetic,
pubmed-meshheading:1982555-Trypanosoma brucei brucei,
pubmed-meshheading:1982555-Variant Surface Glycoproteins, Trypanosoma
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pubmed:year |
1990
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pubmed:articleTitle |
Differential expression of a family of putative adenylate/guanylate cyclase genes in Trypanosoma brucei.
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pubmed:affiliation |
Department of Molecular Biology, University of Brussels, Rhode St.-Genèse, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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