Linked Life Data

1982529

Source:http://linkedlifedata.com/resource/pubmed/id/1982529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-6-3
pubmed:abstractText
The methylation status of the c-H-ras-1, insulin and retinoblastoma genes was determined in human sperm, hydatidiform mole, fetal tissues, adult lymphocytes and adult kidney. Individual alleles of c-H-ras-1 and insulin were distinguishable due to presence of endogenous variable number of tandem repeat (VNTR) polymorphisms. Both alleles of the latter two genes were extensively methylated in sperm compared to the other tissues. Several sites within these genes were less methylated in fetal tissues and the two alleles were differentially methylated in some cases. The retinoblastoma gene was highly methylated in all tissues examined, with the exception of a single site that was under-methylated in sperm only. The sperm-specific methylation patterns in all three genes could represent imprinting of the parental chromosomes. Since 5-methylcytosine is inherently mutagenic, it is possible that methylation imprinting could alter the susceptibilities of human genes to point mutations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-23
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Changes in the allelic methylation patterns of c-H-ras-1, insulin and retinoblastoma genes in human development.
pubmed:affiliation
Department of Biochemistry, University of Southern California Medical School, Los Angeles 90033.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.