Linked Life Data

19823194

Source:http://linkedlifedata.com/resource/pubmed/id/19823194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-10-16
pubmed:abstractText
The past few years have seen the identification of dozens of genes with causal roles in motor neuron diseases (MNDs), particularly for amyotrophic lateral sclerosis and hereditary spastic paraplegia. Although many additional MND genes remain to be identified, the accumulated genetic evidence has already provided new insights into MND pathogenesis, which adds to the well-established involvement of superoxide dismutase 1 (SOD1) mutations. The pathways that have been recently implicated include those that affect RNA processing, axonal transport and mitochondrial function. The functional classes of MND genes identified so far are likely to aid the selection of high-priority candidate genes for future investigation, including those for so-called sporadic cases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1471-0064
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
769-82
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Genetics of motor neuron disorders: new insights into pathogenic mechanisms.
pubmed:affiliation
Centre Hospitalier Universitaire Sainte-Justine Research Center, Centre of Excellence in Neuromics, Universit de Montral, Quebec H2L 2W5, Canada.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't