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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2009-10-13
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pubmed:abstractText |
Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of certain chemotherapy and molecular targeted agents. However, the resultant effect of such induction on patient outcome has received limited study.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1526-632X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1207-13
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pubmed:dateRevised |
2010-10-14
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pubmed:meshHeading |
pubmed-meshheading:19822870-Adult,
pubmed-meshheading:19822870-Aged,
pubmed-meshheading:19822870-Anticonvulsants,
pubmed-meshheading:19822870-Antineoplastic Agents,
pubmed-meshheading:19822870-Brain Neoplasms,
pubmed-meshheading:19822870-Cross-Sectional Studies,
pubmed-meshheading:19822870-Disease-Free Survival,
pubmed-meshheading:19822870-Enzyme Induction,
pubmed-meshheading:19822870-Female,
pubmed-meshheading:19822870-Glioblastoma,
pubmed-meshheading:19822870-Humans,
pubmed-meshheading:19822870-Male,
pubmed-meshheading:19822870-Middle Aged,
pubmed-meshheading:19822870-Seizures,
pubmed-meshheading:19822870-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma.
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pubmed:affiliation |
Mayo Clinic, Jacksonville, FL 32224, USA. jaeckle.kurt@mayo.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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