Source:http://linkedlifedata.com/resource/pubmed/id/19822096
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2009-10-13
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| pubmed:abstractText |
Myelodysplastic Syndrome (MDS) cells present genetic instability and dysregulation of the gene C3ORF9, which was isolated from an MDS cDNA library and codes for a putative protein. We studied the expression of C3ORF9 in MDS syndromes to contribute to the understanding of the pathophysiology of MDS. One hundred and thirty-one patients and 35 healthy controls were involved in our study. Bone marrow aspirates and isolated CD34+ cells were used. Gene expression was estimated by quantitative PCR. C3ORF9 was found to be down-regulated in patients with CMML compared to the controls (p<0.01). There was no difference between RARS and the controls (p=0.1), while increased expression was found in RA, RAEB and RAEB-T (p<0.01 for all). No mutations or polymorphism were detected in our population. CD34+ cells expressed higher levels of C3ORF9 (p<0.01) in patients. The gene expression was correlated to the percentage of +cells in RAEB and RAEB-T (r=0.64). The altered C3ORF9 expression was possibly due to different gene regulation in these patients and/or to the increased CD34+ cells.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0394-6320
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
787-93
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19822096-Adult,
pubmed-meshheading:19822096-Aged,
pubmed-meshheading:19822096-Aged, 80 and over,
pubmed-meshheading:19822096-Antigens, CD34,
pubmed-meshheading:19822096-Bone Marrow Cells,
pubmed-meshheading:19822096-Case-Control Studies,
pubmed-meshheading:19822096-Chromosome Aberrations,
pubmed-meshheading:19822096-DNA Mutational Analysis,
pubmed-meshheading:19822096-Female,
pubmed-meshheading:19822096-Gene Expression Regulation,
pubmed-meshheading:19822096-Glucosyltransferases,
pubmed-meshheading:19822096-Humans,
pubmed-meshheading:19822096-Karyotyping,
pubmed-meshheading:19822096-Male,
pubmed-meshheading:19822096-Middle Aged,
pubmed-meshheading:19822096-Myelodysplastic Syndromes,
pubmed-meshheading:19822096-Proteins,
pubmed-meshheading:19822096-Reverse Transcriptase Polymerase Chain Reaction
|
| pubmed:articleTitle |
Abnormal expression of C3ORF9 gene in patients with myelodysplastic syndromes.
|
| pubmed:affiliation |
University Hospital of Larisa, Medical School, University of Thessalia, Greece.
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| pubmed:publicationType |
Journal Article
|