Source:http://linkedlifedata.com/resource/pubmed/id/19821488
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2010-3-29
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| pubmed:abstractText |
Although marked differences in anthropometric characteristics and malignant lymphoma (ML) incidence suggest that the association between obesity and ML risk in Asian and non-Asian populations may differ, few studies have investigated this association in Asian populations. Here, we conducted a sex- and age-matched case-control study in a Japanese population using 782 cases and 3,910 noncancer controls in the hospital-based Epidemiological Research Program at Aichi Cancer Center Hospital. Odds ratios (ORs) and 95% confidence intervals (CIs) for anthropometric characteristics were estimated using a conditional logistic regression model that incorporated smoking and alcohol intake. Recent body weight and body mass index (BMI) showed marginally significant association with ML risk (ORs [95% CIs] per 5-unit increase in recent weight and BMI; 1.04 [0.99-1.09] and 1.11 [0.98-1.27], respectively). On the other hand, weight and BMI in early adulthood exhibited a strong association with ML risk (ORs [95% CIs] per 5-unit increase in early adulthood weight and BMI; 1.11 [1.05-1.18] and 1.33 [1.13-1.55], respectively). Further, in women, a BMI of 25.0-29.9 kg/m(2), defined as obesity in Asian populations, during early adulthood was significantly associated with ML risk compared to the normal range of 18.5-22.9 kg/m(2). By histological ML subtype, the point estimates of ORs for obesity relative to normal weight in early adulthood were over unity for non-Hodgkin lymphoma (NHL) as a whole and significant for diffuse large B-cell lymphoma (DLBCL). In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1097-0215
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
126
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2416-25
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| pubmed:meshHeading |
pubmed-meshheading:19821488-Adult,
pubmed-meshheading:19821488-Age Distribution,
pubmed-meshheading:19821488-Age Factors,
pubmed-meshheading:19821488-Aged,
pubmed-meshheading:19821488-Aged, 80 and over,
pubmed-meshheading:19821488-Asian Continental Ancestry Group,
pubmed-meshheading:19821488-Body Mass Index,
pubmed-meshheading:19821488-Body Weight,
pubmed-meshheading:19821488-Case-Control Studies,
pubmed-meshheading:19821488-Confidence Intervals,
pubmed-meshheading:19821488-Female,
pubmed-meshheading:19821488-Hodgkin Disease,
pubmed-meshheading:19821488-Humans,
pubmed-meshheading:19821488-Japan,
pubmed-meshheading:19821488-Logistic Models,
pubmed-meshheading:19821488-Lymphoma,
pubmed-meshheading:19821488-Lymphoma, Non-Hodgkin,
pubmed-meshheading:19821488-Male,
pubmed-meshheading:19821488-Middle Aged,
pubmed-meshheading:19821488-Obesity,
pubmed-meshheading:19821488-Odds Ratio,
pubmed-meshheading:19821488-Risk Assessment,
pubmed-meshheading:19821488-Risk Factors,
pubmed-meshheading:19821488-Sex Distribution,
pubmed-meshheading:19821488-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Association between obesity and the risk of malignant lymphoma in Japanese: a case-control study.
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| pubmed:affiliation |
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|