Linked Life Data

1982055

Source:http://linkedlifedata.com/resource/pubmed/id/1982055

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-5-16
pubmed:abstractText
The results presented indicate that L-glutamate is involved in mediating excitatory afferent neuro-transmission in the mammalian cochlea. Glutamate applied directly into the subsynaptic inner hair cell region of the adult guinea pig with the aid of microiontophoretic techniques evoked neuronal firing. By using competitive antagonists for glutamate receptors, a further study was carried out in order to identify possible receptor types. Such included N-methyl-D-aspartate (NMDA), kainate and quisqualate receptors, which are defined by selective agonist action. The glutamate-induced cochlear firing rate was antagonized by D-2-amino-7-phosphonoheptanoate (AP-7), suggesting that the receptor involved is of the NMDA type. Further studies with glutamic acid diethylester (GDEE) showed that glutamate-induced activity could also be blocked by this substance. Since GDEE depresses responses to quisqualate, non-NMDA receptors also have to be taken into consideration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0937-4477
pubmed:author
pubmed:issnType
Print
pubmed:volume
248
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-3
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
A microiontophoretic study of the role of excitatory amino acids at the afferent synapses of mammalian inner hair cells.
pubmed:affiliation
Division of Neurobiology, University of Berne, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't