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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-5
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pubmed:abstractText |
Maternal subclinical hypothyroidism is associated with a number of adverse outcomes in pregnancy. The Endocrine Society's recent consensus guidelines have recommended treatment with T(4) for this condition in pregnancy. The single nucleotide polymorphism rs4704397 in the phosphodiesterase 8B (PDE8B) gene has been found to be associated with altered serum TSH concentrations in the general population. We aimed to assess whether genetic variation in TSH due to the rs4704397 genotype affects the number of individuals classified as having subclinical hypothyroidism in pregnancy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1945-7197
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4608-12
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pubmed:meshHeading |
pubmed-meshheading:19820008-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:19820008-Autoantibodies,
pubmed-meshheading:19820008-Base Sequence,
pubmed-meshheading:19820008-Female,
pubmed-meshheading:19820008-Genetic Variation,
pubmed-meshheading:19820008-Genotype,
pubmed-meshheading:19820008-Humans,
pubmed-meshheading:19820008-Hypothyroidism,
pubmed-meshheading:19820008-Iodide Peroxidase,
pubmed-meshheading:19820008-Polymorphism, Genetic,
pubmed-meshheading:19820008-Pregnancy,
pubmed-meshheading:19820008-Thyrotropin
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pubmed:year |
2009
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pubmed:articleTitle |
Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy.
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pubmed:affiliation |
Peninsula National Institute for Health Research Clinical Research Facility, Peninsula Medical School, Exeter University, Exeter EX2 5DW, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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