Source:http://linkedlifedata.com/resource/pubmed/id/19819355
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0015252,
umls-concept:C0029418,
umls-concept:C0031700,
umls-concept:C0038884,
umls-concept:C0040302,
umls-concept:C0087111,
umls-concept:C0205148,
umls-concept:C0376590,
umls-concept:C0441722,
umls-concept:C0728940,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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| pubmed:issue |
4
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| pubmed:dateCreated |
2010-3-1
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| pubmed:abstractText |
This study investigated the surface characteristics and biocompatibility of phosphate ion (P)-incorporated titanium (Ti) surfaces hydrothermally treated with various concentrations of phosphoric acid (H(3)PO(4)). The surface characteristics were evaluated by scanning electron microscopy, thin-film X-ray diffractometry, X-ray photoelectron spectroscopy, optical profilometry, contact angle and surface energy measurement and inductively coupled plasma mass spectroscopy (ICP-MS). MC3T3-E1 cell attachment, spreading, proliferation and osteoblastic gene expression on different surfaces were evaluated. The degree of bony integration was biomechanically evaluated by removal torque testing after 4 weeks of healing in rabbit tibiae. The H(3)PO(4) treatment produced micro-rough Ti surfaces with crystalline P-incorporated Ti oxide layers. High concentration H(3)PO(4) treatment (1% and 2%) produced significantly higher hydrophilic surfaces compared with low H(3)PO(4) treatment (0.5%) and untreated surfaces (P<0.01). ICP-MS analysis showed P ions were released from P-incorporated surfaces. Significant increased cell attachment (P<0.05) and notably higher mRNA expressions of Runx2, alkaline phosphatase, osteopontin and osteocalcin were observed in cells grown on P-incorporated surfaces compared with cells on untreated machined surfaces. P-incorporated surfaces showed significantly higher removal torque forces compared with untreated machined implants (P<0.05). Ti surfaces treated with 2% H(3)PO(4) showed increasing tendencies in osteoblastic gene expression and removal torque forces compared with those treated with lower H(3)PO(4) concentrations or untreated surfaces. These results demonstrate that H(3)PO(4) treatment may improve the biocompatibility of Ti implants by enhancing osteoblast attachment, differentiation and biomechanical anchorage.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1878-7568
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
6
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1661-70
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| pubmed:meshHeading |
pubmed-meshheading:19819355-Animals,
pubmed-meshheading:19819355-Biomechanics,
pubmed-meshheading:19819355-Cell Adhesion,
pubmed-meshheading:19819355-Cell Count,
pubmed-meshheading:19819355-Cell Line,
pubmed-meshheading:19819355-Cell Movement,
pubmed-meshheading:19819355-Cell Proliferation,
pubmed-meshheading:19819355-Cell Shape,
pubmed-meshheading:19819355-Gene Expression Regulation,
pubmed-meshheading:19819355-Male,
pubmed-meshheading:19819355-Mice,
pubmed-meshheading:19819355-Microscopy, Electron, Scanning,
pubmed-meshheading:19819355-Osteoblasts,
pubmed-meshheading:19819355-Phosphoric Acids,
pubmed-meshheading:19819355-Photoelectron Spectroscopy,
pubmed-meshheading:19819355-RNA, Messenger,
pubmed-meshheading:19819355-Rabbits,
pubmed-meshheading:19819355-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19819355-Surface Properties,
pubmed-meshheading:19819355-Titanium,
pubmed-meshheading:19819355-Torque,
pubmed-meshheading:19819355-X-Ray Diffraction
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| pubmed:year |
2010
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| pubmed:articleTitle |
Effects of phosphoric acid treatment of titanium surfaces on surface properties, osteoblast response and removal of torque forces.
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| pubmed:affiliation |
Department of Periodontology, School of Dentistry, Kyungpook National University, 188-1, Samduk 2Ga, Jung-Gu, Daegu 700-412, Republic of Korea. jinwoo@knu.ac.kr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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