Linked Life Data

19819150

Source:http://linkedlifedata.com/resource/pubmed/id/19819150

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2009-11-2
pubmed:abstractText
A series of benzazolone compounds were synthesized utilizing benzoxazolinonic and benzothiazolinonic heterocycles as the building unit. The antioxidant activity of these compounds was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO(4) or 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The protective action of these compounds against the cytotoxicity was evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). The best antioxidant activities were observed for phenolic compounds 13 and 14b with ratio R=2.5, 3.2 (5microM). Both of these test substances increased the cell viability significantly as indicated by MTT assay and LDH release assay.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1464-3391
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7823-30
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model.
pubmed:affiliation
Faculté de Pharmacie, Université Lille Nord de France, Laboratoire de Chimie Thérapeutique (EA 1043)3, Rue du Professeur Laguesse, BP 83, 59006 LILLE Cedex, France.
pubmed:publicationType
Journal Article