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rdf:type |
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lifeskim:mentions |
umls-concept:C0001779,
umls-concept:C0008059,
umls-concept:C0018479,
umls-concept:C0018483,
umls-concept:C0027442,
umls-concept:C0032594,
umls-concept:C0033684,
umls-concept:C0038410,
umls-concept:C0042196,
umls-concept:C0205151,
umls-concept:C0305065,
umls-concept:C0439234,
umls-concept:C0522529,
umls-concept:C1280500
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-1
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pubmed:abstractText |
Following primary and booster vaccination with an 11-valent pneumococcall protein D conjugate vaccine there was a 42.8% (95% CI: -16.7 to 71.9, ns) reduction in the carriage of Streptococcus pneumoniae vaccine serotypes and a 42.6% (95% CI: 1.3-66.6) reduction in the carriage of Haemophilus influenzae identified by standard microbiological techniques. When PCR and immunoblot assays were used to further improve specificity of non-typeable H. influenzae strain identification, carriage of H. influenzae was still reduced with 38.6% (95% CI: -6.3 to 64.6, ns). Reduction of acute otitis media (AOM) episodes preceded the impact on carriage. These data provide further support of the functional role of the protein D immunity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin D,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pneumococcal Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Conjugate,
http://linkedlifedata.com/resource/pubmed/chemical/glpQ protein, Haemophilus influenzae
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1873-2518
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-8
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pubmed:meshHeading |
pubmed-meshheading:19818722-Bacterial Proteins,
pubmed-meshheading:19818722-Carrier Proteins,
pubmed-meshheading:19818722-Carrier State,
pubmed-meshheading:19818722-Child, Preschool,
pubmed-meshheading:19818722-DNA, Bacterial,
pubmed-meshheading:19818722-Double-Blind Method,
pubmed-meshheading:19818722-Female,
pubmed-meshheading:19818722-Haemophilus Infections,
pubmed-meshheading:19818722-Humans,
pubmed-meshheading:19818722-Immunoglobulin D,
pubmed-meshheading:19818722-Infant,
pubmed-meshheading:19818722-Lipoproteins,
pubmed-meshheading:19818722-Male,
pubmed-meshheading:19818722-Nasopharynx,
pubmed-meshheading:19818722-Otitis Media,
pubmed-meshheading:19818722-Pneumococcal Infections,
pubmed-meshheading:19818722-Pneumococcal Vaccines,
pubmed-meshheading:19818722-Polysaccharides, Bacterial,
pubmed-meshheading:19818722-Prospective Studies,
pubmed-meshheading:19818722-Vaccines, Conjugate
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pubmed:year |
2009
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pubmed:articleTitle |
Effect of vaccination with pneumococcal capsular polysaccharides conjugated to Haemophilus influenzae-derived protein D on nasopharyngeal carriage of Streptococcus pneumoniae and H. influenzae in children under 2 years of age.
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pubmed:affiliation |
Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. prymula@pmfhk.cz
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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