Linked Life Data

1981857

Source:http://linkedlifedata.com/resource/pubmed/id/1981857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1991-5-1
pubmed:abstractText
Previous studies reported that norepinephrine (NE) induces contraction of the calf isolated coronary arteries after beta-adrenergic blockade with propranolol (PR), and that the effect disappeared after phentolamine. An higher Ca++ concentration increased the response of preparation to NE, whereas the reduction of the concentration reduced the response. In isolated coronary arteries the baseline tone and contractile response to NE after PR were studied as influenced by DA and nicardipine (NI). NI always induced vessel relaxation and DA induced a contraction followed by relaxation. The NE contraction was not abolished in calcium-free medium but in presence of DA and was reduced by NI in the medium containing Ca++. We conclude that NE induces contractions by facilitating the influx of the extracellular Ca++ and by promoting the liberation of intracellular bound Ca++.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0393-1978
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
635-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[The role of intra- and extracellular Ca++ in coronary vessel contraction induced in vitro by noradrenaline following a beta-adrenergic block].
pubmed:affiliation
Istituto di Fisiologia Umana, Università degli Studi, Padova.
pubmed:publicationType
Journal Article, In Vitro, English Abstract