Linked Life Data

19818523

Source:http://linkedlifedata.com/resource/pubmed/id/19818523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-10-20
pubmed:abstractText
Advances in genomic technologies have made it possible to screen the entire cancer genome for mutations, leading to a better understanding of the genetic landscape of cancer. Emerging results suggest that the cancer genome is composed of a few commonly mutated genes and many infrequently mutated genes. Although the number of mutated genes in any one tumor is limited, there is much heterogeneity in the genes mutated in two tumors of even the same class because of the large number of infrequently mutated genes. This could explain the wide variation in tumor behavior to chemotherapeutic intervention. Pathway analysis suggests this large collection of cancer genes functions in a few signaling pathways, providing a simplifying picture of cancer, and indicating the possibility of treating cancer using target-based therapeutics directed against the deregulated signaling pathways themselves rather than the individually mutated genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0168-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-62
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Deciphering the genetic landscape of cancer--from genes to pathways.
pubmed:affiliation
Genomics and Genetics Division, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, Proteos, Singapore 138673. ncopeland@imcb.a-star.edu.sg
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't