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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-10
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pubmed:abstractText |
Restless legs syndrome (RLS) is a neurological disorder that is thought to involve decreased iron availability in the brain. Iron is required for oxidative metabolism and plays a critical role in redox reactions in mitochondria. The recent discovery of mitochondrial ferritin (FtMt) provided the opportunity to identify a potential correlation between iron and mitochondrial function in RLS. Human substantia nigra (SN) and putamen autopsy samples from 8 RLS cases and 8 controls were analyzed. Mitochondrial ferritin levels in RLS SN tissue homogenate samples assessed by immunoblots had more FtMt than control samples (p < 0.01), whereas there were no significant differences in FtMt in the putamen samples. By immunohistochemistry, neuromelanin-containing neurons in the SN were the predominant cell type expressing FtMt. Staining in neurons in RLS samples was consistently greater than that in controls. Cytochrome c oxidase staining, which reflects numbers of mitochondria, showed a similar staining pattern to that of FtMt, whereas there was less immunostaining in the RLS cases for cytosolic H-ferritin. These results suggest that increased numbers of mitochondria in neurons in RLS and increased FtMt might contribute to insufficient cytosolic iron levels in RLS SN neurons; they are consistent with the hypothesis that energy insufficiency in these neurons may be involved in the pathogenesis of RLS.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3069
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1193-9
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:19816198-Aged,
pubmed-meshheading:19816198-Aged, 80 and over,
pubmed-meshheading:19816198-Cytosol,
pubmed-meshheading:19816198-Female,
pubmed-meshheading:19816198-Ferritins,
pubmed-meshheading:19816198-Humans,
pubmed-meshheading:19816198-Iron,
pubmed-meshheading:19816198-Male,
pubmed-meshheading:19816198-Middle Aged,
pubmed-meshheading:19816198-Mitochondrial Proteins,
pubmed-meshheading:19816198-Neurons,
pubmed-meshheading:19816198-Restless Legs Syndrome,
pubmed-meshheading:19816198-Substantia Nigra
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pubmed:year |
2009
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pubmed:articleTitle |
Mitochondrial ferritin in the substantia nigra in restless legs syndrome.
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pubmed:affiliation |
Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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