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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
The modulation of the hepatic acute-phase reaction (APR) that occurs during inflammation and liver regeneration is important for allowing normal hepatocellular proliferation and the restoration of homeostasis. Activation of acute-phase protein (APP) gene expression by interleukin-6 (IL-6)-type cytokines is thought to be counteracted by growth factors released during hepatic inflammation and regeneration. The epidermal growth factor receptor (EGFR) ligand amphiregulin (AR) is readily induced by inflammatory signals and plays a nonredundant protective role during liver injury. In this paper, we investigated the role of AR as a modulator of liver APP gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acute-Phase Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Oncostatin M,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/alpha 1-Antichymotrypsin,
http://linkedlifedata.com/resource/pubmed/chemical/amphiregulin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0168-8278
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pubmed:author |
pubmed-author:Alvarez-AsiainLauraL,
pubmed-author:AvilaMatías AMA,
pubmed-author:BerasainCarmenC,
pubmed-author:CastilloJosefaJ,
pubmed-author:LatasaMaria UjueMU,
pubmed-author:Pardo-SagantaAnaA,
pubmed-author:PerugorríaMaría JMJ,
pubmed-author:PrietoJesúsJ,
pubmed-author:Rodriguez-OrtigosaCarlos MCM,
pubmed-author:SantamaríaMónicaM,
pubmed-author:SarobePabloP
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1010-20
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pubmed:meshHeading |
pubmed-meshheading:19815304-Acute-Phase Proteins,
pubmed-meshheading:19815304-Acute-Phase Reaction,
pubmed-meshheading:19815304-Animals,
pubmed-meshheading:19815304-Base Sequence,
pubmed-meshheading:19815304-Cell Line, Tumor,
pubmed-meshheading:19815304-DNA Primers,
pubmed-meshheading:19815304-Gene Expression Regulation,
pubmed-meshheading:19815304-Glycoproteins,
pubmed-meshheading:19815304-Hepatocytes,
pubmed-meshheading:19815304-Humans,
pubmed-meshheading:19815304-Inflammation,
pubmed-meshheading:19815304-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19815304-Ligands,
pubmed-meshheading:19815304-Lipopolysaccharides,
pubmed-meshheading:19815304-Liver,
pubmed-meshheading:19815304-Liver Regeneration,
pubmed-meshheading:19815304-Male,
pubmed-meshheading:19815304-Mice,
pubmed-meshheading:19815304-Mice, Knockout,
pubmed-meshheading:19815304-Oncostatin M,
pubmed-meshheading:19815304-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19815304-Recombinant Proteins,
pubmed-meshheading:19815304-STAT3 Transcription Factor,
pubmed-meshheading:19815304-Signal Transduction,
pubmed-meshheading:19815304-alpha 1-Antichymotrypsin
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pubmed:year |
2009
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pubmed:articleTitle |
The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression.
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pubmed:affiliation |
Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Avda. Pio XII n. 55, 31008 Pamplona, Spain.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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