|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2009-10-9
|
|
pubmed:abstractText |
This study focuses on the in-vitro metabolic profiles of pentamethylchromanol in human, rat, dog and non-human primates, and characterizes the associated metabolic kinetics and specific human isozymes responsible for metabolism. Additional investigations compare in-vitro data with in-vivo metabolic data from rats and dogs.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
2042-7158
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
61
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1309-18
|
|
pubmed:dateRevised |
2011-9-13
|
|
pubmed:meshHeading |
pubmed-meshheading:19814862-Animals,
pubmed-meshheading:19814862-Chromans,
pubmed-meshheading:19814862-Chromatography, Liquid,
pubmed-meshheading:19814862-Dogs,
pubmed-meshheading:19814862-Female,
pubmed-meshheading:19814862-Humans,
pubmed-meshheading:19814862-Isoenzymes,
pubmed-meshheading:19814862-Male,
pubmed-meshheading:19814862-Metabolic Detoxication, Drug,
pubmed-meshheading:19814862-Microsomes, Liver,
pubmed-meshheading:19814862-Primates,
pubmed-meshheading:19814862-Rats,
pubmed-meshheading:19814862-Rats, Sprague-Dawley,
pubmed-meshheading:19814862-Species Specificity,
pubmed-meshheading:19814862-Tandem Mass Spectrometry
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
In-vitro and in-vivo metabolic studies of the candidate chemopreventative pentamethylchromanol using liquid chromatography/tandem mass spectrometry.
|
|
pubmed:affiliation |
Toxicology and Bioanalytical Science Department, Southern Research Institute, Birmingham, AL 35205, USA. gorman@southernresearch.org
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, N.I.H., Extramural
|
