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pubmed:abstractText |
Bioassays are routinely used to evaluate the toxicity of test agents. Experimental designs for bioassays are largely encompassed by fixed effects linear models. In toxicogenomics studies where DNA arrays measure mRNA levels, the tissue samples are typically generated in a bioassay. These measurements introduce additional sources of variation, which must be properly managed to obtain valid tests of treatment effects.
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pubmed:affiliation |
Biometry Branch, Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. rdelongchamp@uams.edu
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