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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
Paired immunoglobulin-like type 2 receptor alpha (PILRalpha) is an inhibitory receptor expressed on both hematopoietic and nonhematopoietic cells. Its binding to a cellular ligand, CD99, depends on the presence of sialylated O-linked glycans on CD99. Glycoprotein B (gB) of herpes simplex virus type 1 (HSV-1) binds to PILRalpha, and this association is involved in HSV-1 infection. Here, we found that the presence of sialylated O-glycans on gB is required for gB to associate with PILRalpha. Furthermore, we identified two threonine residues on gB that are essential for the addition of the principal O-glycans acquired by gB and that are also essential for the binding of PILRalpha to gB.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-10720325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-14657396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-14970179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-15385431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-16840698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-17229687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-17666526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-18209065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-18234675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-18358807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-19369321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-19457990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-2509474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-3022014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-8297327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19812165-8709230
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13042-5
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB.
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pubmed:affiliation |
Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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