|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0022801,
umls-concept:C0036638,
umls-concept:C0301630,
umls-concept:C0332466,
umls-concept:C0442335,
umls-concept:C1160185,
umls-concept:C1514562,
umls-concept:C1622204,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2767814
|
|
pubmed:dateCreated |
2009-10-19
|
|
pubmed:abstractText |
Lentiviral vectors are well suited for gene therapy because they can mediate long-term expression in both dividing and nondividing cells. However, lentiviral vectors seem less suitable for liver gene therapy because systemically administered lentiviral vectors are preferentially sequestered by liver macrophages. This results in a reduction of available virus and might also increase the immune response to the vector and vector products.Reduction of macrophage sequestration is therefore essential for efficient lentiviral liver gene therapy.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-10097153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-10680011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-10738547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-10944446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-11273773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-11604321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-11812281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-11892251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-11892252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-11943415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-12027561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-12161186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-12186920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-12231171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-12573060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-14599800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-14737086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-14759812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-14978753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-15585403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-15727944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-15771967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-15886327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-1660837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-17630838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-2983337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-4357516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-4361457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-8637876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-8930653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-9325155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-9573308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19811629-9636281
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1472-6750
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
85
|
|
pubmed:dateRevised |
2010-9-27
|
|
pubmed:meshHeading |
pubmed-meshheading:19811629-Animals,
pubmed-meshheading:19811629-Cell Line, Tumor,
pubmed-meshheading:19811629-Genetic Vectors,
pubmed-meshheading:19811629-Hepatocytes,
pubmed-meshheading:19811629-Humans,
pubmed-meshheading:19811629-Lentivirus,
pubmed-meshheading:19811629-Liver,
pubmed-meshheading:19811629-Macrophages,
pubmed-meshheading:19811629-Male,
pubmed-meshheading:19811629-Mice,
pubmed-meshheading:19811629-Nucleopolyhedrovirus,
pubmed-meshheading:19811629-Sendai virus,
pubmed-meshheading:19811629-Transduction, Genetic,
pubmed-meshheading:19811629-Viral Fusion Proteins
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain.
|
|
pubmed:affiliation |
AMC Liver Center, Amsterdam, The Netherlands. dmarkusic@ufl.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
