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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-11-11
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pubmed:abstractText |
Maternal diabetes is associated with morphological placental abnormalities and foeto-placental impairments. These alterations are linked with a dysregulation of the activity of matrix metalloproteinases (MMPs). We investigated the action of 15deoxyDelta(12,14) prostaglandin J(2) (15dPGJ(2)), a natural ligand of the peroxisome proliferator activated receptor (PPAR) gamma, on MMP-2 and MMP-9 activities and tissue inhibitors of matrix metalloproteinases (TIMP) levels in foetuses and placentas from diabetic rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1365-2362
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1082-90
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pubmed:meshHeading |
pubmed-meshheading:19811527-Animals,
pubmed-meshheading:19811527-Diabetes Mellitus,
pubmed-meshheading:19811527-Disease Models, Animal,
pubmed-meshheading:19811527-Female,
pubmed-meshheading:19811527-Fetus,
pubmed-meshheading:19811527-Gelatinases,
pubmed-meshheading:19811527-Matrix Metalloproteinases,
pubmed-meshheading:19811527-Nitric Oxide,
pubmed-meshheading:19811527-PPAR gamma,
pubmed-meshheading:19811527-Placenta,
pubmed-meshheading:19811527-Pregnancy,
pubmed-meshheading:19811527-Prostaglandin D2,
pubmed-meshheading:19811527-Rats,
pubmed-meshheading:19811527-Rats, Wistar,
pubmed-meshheading:19811527-Tissue Inhibitor of Metalloproteinases
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pubmed:year |
2009
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pubmed:articleTitle |
MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats.
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pubmed:affiliation |
Laboratory of Reproduction and Metabolism, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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