Source:http://linkedlifedata.com/resource/pubmed/id/19811440
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3-4
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pubmed:dateCreated |
2009-10-8
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pubmed:abstractText |
The aim of the study was to assess whether genotypes in the Toll-like receptor 4 gene and in the promoter of the interleukin-18 gene are associated with the susceptibility to chronic periodontitis. 108 chronic periodontitis patients and 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) and for c.-368G>C/ c.-838C>A (IL-18 promoter). There were no significant differences in genotype and allele distributions between the study groups. Periodontitis severity in patients with TLR4 c.896AG/1196CT genotype was significantly higher than wildtype carriers. The percentage of teeth with clinical attachment loss > or = 5 mm was 77.3% and 58.8%, respectively (p < or = 0.006, t-test). All subjects were further classified into carriers and non-carriers of at least one variant of each gene. A logistic regression analysis adjusted for gender, smoking, and age showed no association between gene variant carrier status and periodontitis (OR = 1.98, 95% CI 0.61-6.39). The results did not show that IL-18 and TLR4 variants have an effect on the susceptibility to chronic periodontitis. Considering the low number of periodontitis patients carrying TLR4 variants (11%), a comparison of the periodontitis severity depending on the genotype has to be interpreted cautiously.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1532-4311
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
297-310
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pubmed:meshHeading |
pubmed-meshheading:19811440-Case-Control Studies,
pubmed-meshheading:19811440-Chronic Periodontitis,
pubmed-meshheading:19811440-Female,
pubmed-meshheading:19811440-Genetic Predisposition to Disease,
pubmed-meshheading:19811440-Genome-Wide Association Study,
pubmed-meshheading:19811440-Genotype,
pubmed-meshheading:19811440-Humans,
pubmed-meshheading:19811440-Interleukin-18,
pubmed-meshheading:19811440-Male,
pubmed-meshheading:19811440-Middle Aged,
pubmed-meshheading:19811440-Polymerase Chain Reaction,
pubmed-meshheading:19811440-Polymorphism, Single Nucleotide,
pubmed-meshheading:19811440-Promoter Regions, Genetic,
pubmed-meshheading:19811440-Toll-Like Receptor 4
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pubmed:year |
2009
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pubmed:articleTitle |
TLR4 and IL-18 gene variants in chronic periodontitis: impact on disease susceptibility and severity.
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pubmed:affiliation |
Department of Conservative Dentistry and Periodontology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany. Barbara.Noack@uniklinikum-dresden.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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