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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-3-25
|
| pubmed:abstractText |
Somatic cell hybrids, recombinant inbred (RI) strains, and progeny of an intersubspecific backcross were typed by Southern blot analysis to prepare a linkage map of mouse chromosome 10. The seven genetic markers in this map, four of which had not previously been positioned, include genes involved in oncogenesis (Gli, Myb, Tra-1), proviral integration (Emv-25), and immune responses (Ifg, Ifgr, Pfp). The linkage map spans much of the chromosome and covers a region of the mouse genome with few molecular markers. The gene order established here demonstrates that the genes for murine interferon-gamma (Ifg) and its receptor (Ifgr) are at opposite ends of the chromosome and that Ifgr and the Myb oncogene are closely linked, a factor that may be related to their joint transcriptional enhancement in some plasmacytoid lymphosarcomas.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0888-7543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:geneSymbol |
Emv-25,
HK-1,
IFNGR1,
IGNGR1,
Ifg,
Ifgr,
MYB,
Pfp,
v-myb
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
519-24
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:1981053-Animals,
pubmed-meshheading:1981053-Chromosome Mapping,
pubmed-meshheading:1981053-Chromosomes, Human, Pair 6,
pubmed-meshheading:1981053-Cricetinae,
pubmed-meshheading:1981053-Cricetulus,
pubmed-meshheading:1981053-Crosses, Genetic,
pubmed-meshheading:1981053-Gene Expression Regulation,
pubmed-meshheading:1981053-Genes,
pubmed-meshheading:1981053-Genetic Linkage,
pubmed-meshheading:1981053-Genetic Markers,
pubmed-meshheading:1981053-Humans,
pubmed-meshheading:1981053-Hybrid Cells,
pubmed-meshheading:1981053-Mice,
pubmed-meshheading:1981053-Mice, Inbred Strains,
pubmed-meshheading:1981053-Muridae,
pubmed-meshheading:1981053-Oncogenes,
pubmed-meshheading:1981053-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1981053-Recombination, Genetic,
pubmed-meshheading:1981053-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1981053-Species Specificity
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Molecular genetic markers spanning mouse chromosome 10.
|
| pubmed:affiliation |
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|