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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-10-14
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pubmed:abstractText |
There is substantial evidence supporting the role of interferon (IFN)-gamma-producing T helper (T(H)) 1 and interleukin (IL)-17-expressing T(H)17 lymphocytes in multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE). However, to date little is known about the potential cooperative interplay between these 2 cytokines. In the current study, we sought to evaluate the frequency of IFN-gamma-expressing T(H)17 lymphocytes in MS and EAE, and study their recruitment into the central nervous system (CNS).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1531-8249
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
390-402
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pubmed:dateRevised |
2010-8-26
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pubmed:meshHeading |
pubmed-meshheading:19810097-Adult,
pubmed-meshheading:19810097-Animals,
pubmed-meshheading:19810097-Blood-Brain Barrier,
pubmed-meshheading:19810097-Brain,
pubmed-meshheading:19810097-Cell Migration Assays,
pubmed-meshheading:19810097-Cell Migration Inhibition,
pubmed-meshheading:19810097-Central Nervous System,
pubmed-meshheading:19810097-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:19810097-Female,
pubmed-meshheading:19810097-Humans,
pubmed-meshheading:19810097-Interferon-gamma,
pubmed-meshheading:19810097-Interleukin-17,
pubmed-meshheading:19810097-Interleukin-23,
pubmed-meshheading:19810097-Mice,
pubmed-meshheading:19810097-Mice, Inbred C57BL,
pubmed-meshheading:19810097-Middle Aged,
pubmed-meshheading:19810097-Multiple Sclerosis,
pubmed-meshheading:19810097-Multiple Sclerosis, Relapsing-Remitting,
pubmed-meshheading:19810097-T-Lymphocytes,
pubmed-meshheading:19810097-Th1 Cells,
pubmed-meshheading:19810097-Th2 Cells
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pubmed:year |
2009
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pubmed:articleTitle |
Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.
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pubmed:affiliation |
Neuroimmunology Research Unit, Center for Excellence in Neuromics, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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