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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-10-7
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pubmed:abstractText |
Asymmetric dimethylarginine (ADMA)is an endogenous amino acid similar to l-arginine and able to inhibit the enzyme endothelial nitric oxide synthase (eNOS). It is a factor of impaired nitric oxide (NO) synthesis. Serum levels of ADMA in chronic kidney disease (CKD) increase due to defective inactivation and excretion. High ADMA levels are associated with endothelial dysfunction and cardiovascular damage. A linkage between ADMA levels and vascular calcifications of CKD can therefore be hypothesized. This study explores also a possible relation between ADMA and parathyroid hormone (PTH) serum levels, which are known to be linked to increased rates of cardiovascular death.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1121-8428
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
616-22
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pubmed:meshHeading |
pubmed-meshheading:19809994-Adolescent,
pubmed-meshheading:19809994-Adult,
pubmed-meshheading:19809994-Aged,
pubmed-meshheading:19809994-Alkaline Phosphatase,
pubmed-meshheading:19809994-Arginine,
pubmed-meshheading:19809994-Body Mass Index,
pubmed-meshheading:19809994-Calcinosis,
pubmed-meshheading:19809994-Calcium,
pubmed-meshheading:19809994-Coronary Artery Disease,
pubmed-meshheading:19809994-Coronary Vessels,
pubmed-meshheading:19809994-Cross-Sectional Studies,
pubmed-meshheading:19809994-Female,
pubmed-meshheading:19809994-Humans,
pubmed-meshheading:19809994-Hyperparathyroidism, Secondary,
pubmed-meshheading:19809994-Kidney Failure, Chronic,
pubmed-meshheading:19809994-Male,
pubmed-meshheading:19809994-Middle Aged,
pubmed-meshheading:19809994-Parathyroid Hormone,
pubmed-meshheading:19809994-Regression Analysis,
pubmed-meshheading:19809994-Renal Dialysis,
pubmed-meshheading:19809994-Young Adult
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pubmed:articleTitle |
Asymmetric dimethylarginine, vascular calcifications and parathyroid hormone serum levels in hemodialysis patients.
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pubmed:affiliation |
Ospedale Israelitico, Rome, Italy. giorgio.coen@gmail.com
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pubmed:publicationType |
Journal Article
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