Source:http://linkedlifedata.com/resource/pubmed/id/19808969
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
20
|
| pubmed:dateCreated |
2009-10-16
|
| pubmed:abstractText |
The underlying mechanism of the protective and suppressive role of NKT cells in human tumor immunosurveillance remains to be fully elucidated. We show that the frequencies of CD8(+) NKT cells in patients with EBV-associated Hodgkin's lymphoma or nasopharyngeal carcinoma are significantly lower than those in healthy EBV carriers. These CD8(+) NKT cells in tumor patients are also functionally impaired. In human-thymus-severe combined immunodeficient (hu-thym-SCID) chimeras, EBV challenge efficiently promotes the generation of IFN-gamma-biased CD8(+) NKT cells. These cells are strongly cytotoxic, drive syngeneic T cells into a Th1 bias, and enhance T-cell cytotoxicity to EBV-associated tumor cells. Interleukin-4-biased CD4(+) NKT cells are predominately generated in unchallenged chimeras. These cells are noncytotoxic, drive syngeneic T cells into a Th2 bias, and do not affect T-cell cytotoxicity. In humanized xenogeneic tumor-transplanted hu-thym-SCID chimeras, adoptive transfer with EBV-induced CD8(+) NKT cells significantly suppresses tumorigenesis by EBV-associated malignancies. EBV-induced CD8(+) NKT cells are necessary and sufficient to enhance the T-cell immunity to EBV-associated malignancies in the hu-thym-SCID chimeras. CD4(+) NKT cells are synergetic with CD8(+) NKT cells, leading to a more pronounced T-cell antitumor response in the chimeras cotransferred with CD4(+) and CD8(+) NKT cells. Thus, immune reconstitution with EBV-induced CD8(+) NKT cells could be a useful strategy in management of EBV-associated malignancies.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1538-7445
|
| pubmed:author |
pubmed-author:ChunxianDuD,
pubmed-author:HeYulingY,
pubmed-author:JiXiangX,
pubmed-author:JinYouxinY,
pubmed-author:JinquanTanT,
pubmed-author:LangChenC,
pubmed-author:MengjunWuW,
pubmed-author:RuijingXiaoX,
pubmed-author:VogtBB,
pubmed-author:WangYujuanY,
pubmed-author:XXX,
pubmed-author:XintiTanT,
pubmed-author:XiongJieJ,
pubmed-author:XiongTaoT,
pubmed-author:YanpingJiangJ,
pubmed-author:ZhangLijunL,
pubmed-author:ZhouRuiR
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
69
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
7935-44
|
| pubmed:dateRevised |
2011-5-18
|
| pubmed:meshHeading |
pubmed-meshheading:19808969-Animals,
pubmed-meshheading:19808969-Blotting, Western,
pubmed-meshheading:19808969-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19808969-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19808969-Cells, Cultured,
pubmed-meshheading:19808969-Chimera,
pubmed-meshheading:19808969-Epstein-Barr Virus Infections,
pubmed-meshheading:19808969-Female,
pubmed-meshheading:19808969-Flow Cytometry,
pubmed-meshheading:19808969-Herpesvirus 4, Human,
pubmed-meshheading:19808969-Hodgkin Disease,
pubmed-meshheading:19808969-Humans,
pubmed-meshheading:19808969-Interferon-gamma,
pubmed-meshheading:19808969-Interleukin-4,
pubmed-meshheading:19808969-Killer Cells, Natural,
pubmed-meshheading:19808969-Mice,
pubmed-meshheading:19808969-Mice, SCID,
pubmed-meshheading:19808969-Nasopharyngeal Neoplasms,
pubmed-meshheading:19808969-RNA, Messenger,
pubmed-meshheading:19808969-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19808969-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:19808969-Th1 Cells,
pubmed-meshheading:19808969-Thymus Gland
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
EBV-induced human CD8+ NKT cells suppress tumorigenesis by EBV-associated malignancies.
|
| pubmed:affiliation |
Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-related Diseases, Center for Medical Research, Wuhan University School of Medicine, Wuhan, People's Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|