Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-2-19
pubmed:abstractText
The objective of this study was to investigate the gene expression signature of monocyte/macrophages and the pleiotropic effects of atorvastatin on monocytes in atherosclerotic patients. Forty patients with coronary heart diseases were randomly assigned to double-blind therapy with either 20 or 80 mg per day of atorvastatin. Follow-up visits occurred at weeks 6 and 12, including complete chemistry and lipid analyses and quantification of 14 target genes in monocytes. After 12 weeks of therapy, both groups gained beneficial alterations in lipid profiles. Both groups experienced significant reductions in gene expression of lipoprotein-associated phospholipase A2, CD13, leptin receptor, matrix metalloproteases-1, legumain, and prolyl oligopeptidase after 12 weeks of therapy. Only tumor protein 53 was increased in the atorvastatin 80-mg group. Moreover, nonsignificant interactions between dosage and duration of therapy were found. The pleiotropic effects of statins in atherosclerotic patients include increased expression of genes involved in apoptosis of monocyte/macrophage, inhibition of inflammatory responses, antioxidant properties, prevention of foam cell formation, and stabilization of atherosclerotic plaques. This property fuels potential clinical significance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/1-Alkyl-2-acetylglycerophosphocholin..., http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD13, http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin, http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases, http://linkedlifedata.com/resource/pubmed/chemical/asparaginylendopeptidase, http://linkedlifedata.com/resource/pubmed/chemical/atorvastatin, http://linkedlifedata.com/resource/pubmed/chemical/prolyl oligopeptidase
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1552-4604
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-9
pubmed:meshHeading
pubmed-meshheading:19808950-1-Alkyl-2-acetylglycerophosphocholine Esterase, pubmed-meshheading:19808950-Administration, Oral, pubmed-meshheading:19808950-Anticholesteremic Agents, pubmed-meshheading:19808950-Antigens, CD13, pubmed-meshheading:19808950-Apoptosis, pubmed-meshheading:19808950-Atherosclerosis, pubmed-meshheading:19808950-Coronary Disease, pubmed-meshheading:19808950-Cysteine Endopeptidases, pubmed-meshheading:19808950-Dose-Response Relationship, Drug, pubmed-meshheading:19808950-Double-Blind Method, pubmed-meshheading:19808950-Female, pubmed-meshheading:19808950-Follow-Up Studies, pubmed-meshheading:19808950-Gene Expression, pubmed-meshheading:19808950-Heptanoic Acids, pubmed-meshheading:19808950-Humans, pubmed-meshheading:19808950-Lipid Metabolism, pubmed-meshheading:19808950-Male, pubmed-meshheading:19808950-Matrix Metalloproteinase 1, pubmed-meshheading:19808950-Middle Aged, pubmed-meshheading:19808950-Monocytes, pubmed-meshheading:19808950-Pyrroles, pubmed-meshheading:19808950-Receptors, Leptin, pubmed-meshheading:19808950-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19808950-Serine Endopeptidases, pubmed-meshheading:19808950-Time Factors, pubmed-meshheading:19808950-Treatment Outcome
pubmed:year
2010
pubmed:articleTitle
Pleiotropic effects of atorvastatin on monocytes in atherosclerotic patients.
pubmed:affiliation
Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education, Department of Cardiology, Qilu Hospital of Shandong University, Ji'nan, P.R. China.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't