A balance between apoptosis and proliferation of vascular smooth muscle cells (VSMC) influences the development of intimal hyperplasia. We have previously demonstrated that protein kinase C delta (PKCdelta) regulates both apoptosis and proliferation of VSMC in vitro. Here we investigate the role of PKCdelta in intimal hyperplasia through gene deletion or overexpression in rodent models of arterial injury.
Division of Peripheral Vascular Surgery, Department of Surgery, University of Wisconsin Madison, 1111 Highland Avenue, WIMR 5120, Madison, WI 53705, USA.
