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rdf:type |
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lifeskim:mentions |
umls-concept:C0015214,
umls-concept:C0016904,
umls-concept:C0028633,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0079883,
umls-concept:C0127400,
umls-concept:C0449432,
umls-concept:C0597357,
umls-concept:C1179435,
umls-concept:C1517927,
umls-concept:C1519355,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1709059
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pubmed:issue |
1-2
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pubmed:dateCreated |
1991-3-19
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pubmed:abstractText |
In a slice preparation of the rat nucleus accumbens (Acb), local electrical stimulation elicited a field potential composed of two negative peaks, followed by a positive wave. The early negative peak was identified as a non-synaptic compound action potential, the late negative peak as a monosynaptic population spike (PS) and the positive wave as a mixture of an excitatory and an inhibitory postsynaptic potential (PSP). Both the PS and the PSP exhibited a marked degree of paired-pulse facilitation. The quisqualate/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 2 microM) and the broadly acting glutamate receptor antagonist kynurenic acid (300 microM) reversibly abolished or reduced both the PS and PSP. In contrast, nicotinic, muscarinic and N-methyl-D-aspartate (NMDA) receptor antagonists had no suppressive action. Washout of Mg2+ from the superfusion medium reversibly enhanced and prolonged the PSP and this effect was blocked by the NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (D-AP-5). The gamma-aminobutyric acid antagonist picrotoxin (60 microM) enhanced the PS and induced secondary spikes which were superimposed on a prolonged PSP. Most of this prolongation was abolished by D-AP-5. It is concluded that locally evoked synaptic responses in the Acb are mediated by glutamate or aspartate, and that NMDA receptor mediated activity evoked by low frequency stimulation is substantial in Mg2(+)-free medium or during reduced GABAA receptor activity, but not under normal conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Kynurenic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Pentobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/Picrotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridostigmine Bromide,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Tubocurarine,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-glutamylglycine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
529
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1980846-2-Amino-5-phosphonovalerate,
pubmed-meshheading:1980846-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:1980846-Animals,
pubmed-meshheading:1980846-Atropine,
pubmed-meshheading:1980846-Axons,
pubmed-meshheading:1980846-Dipeptides,
pubmed-meshheading:1980846-Electric Stimulation,
pubmed-meshheading:1980846-Evoked Potentials,
pubmed-meshheading:1980846-Kynurenic Acid,
pubmed-meshheading:1980846-Male,
pubmed-meshheading:1980846-Neurons,
pubmed-meshheading:1980846-Neurotoxins,
pubmed-meshheading:1980846-Nucleus Accumbens,
pubmed-meshheading:1980846-Pentobarbital,
pubmed-meshheading:1980846-Picrotoxin,
pubmed-meshheading:1980846-Pyridostigmine Bromide,
pubmed-meshheading:1980846-Quinoxalines,
pubmed-meshheading:1980846-Rats,
pubmed-meshheading:1980846-Rats, Inbred Strains,
pubmed-meshheading:1980846-Receptors, GABA-A,
pubmed-meshheading:1980846-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:1980846-Receptors, Neurotransmitter,
pubmed-meshheading:1980846-Tetrodotoxin,
pubmed-meshheading:1980846-Time Factors,
pubmed-meshheading:1980846-Tubocurarine,
pubmed-meshheading:1980846-gamma-Aminobutyric Acid
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pubmed:year |
1990
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pubmed:articleTitle |
Locally evoked potentials in slices of the rat nucleus accumbens: NMDA and non-NMDA receptor mediated components and modulation by GABA.
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pubmed:affiliation |
Department of Experimental Zoology, University of Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
In Vitro
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