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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-10-7
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pubmed:databankReference |
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pubmed:abstractText |
Loss of negative feedback inhibition of renin release during chronic treatment with an angiotensin-converting enzyme (ACE) inhibitor leads to a compensatory rise in renin secretion and downstream components of the renin-angiotensin-aldosterone (RAAS) cascade. This may overcome ACE inhibition but should be blocked by a direct renin inhibitor. We studied the effects of adding the direct renin inhibitor aliskiren to an ACE inhibitor in patients with heart failure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1941-3297
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-24
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pubmed:meshHeading |
pubmed-meshheading:19808266-Administration, Oral,
pubmed-meshheading:19808266-Adrenergic beta-Antagonists,
pubmed-meshheading:19808266-Aged,
pubmed-meshheading:19808266-Amides,
pubmed-meshheading:19808266-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:19808266-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:19808266-Antihypertensive Agents,
pubmed-meshheading:19808266-Drug Therapy, Combination,
pubmed-meshheading:19808266-Female,
pubmed-meshheading:19808266-Fumarates,
pubmed-meshheading:19808266-Heart Failure,
pubmed-meshheading:19808266-Humans,
pubmed-meshheading:19808266-Hypertension,
pubmed-meshheading:19808266-Male,
pubmed-meshheading:19808266-Natriuretic Peptide, Brain,
pubmed-meshheading:19808266-Severity of Illness Index,
pubmed-meshheading:19808266-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure.
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pubmed:affiliation |
BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom. j.mcmurray@bio.gla.ac.uk
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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